Surprising Causes of Hives — What May Be Triggering Your Skin Reaction

throat tightness, or faintness (possible anaphylaxis).

2) Medications you wouldn’t expect

NSAIDs (e.g., ibuprofen, aspirin) can trigger or worsen hives—particularly in people who already have chronic urticaria; estimates suggest ~20–40% of these patients are sensitive to NSAIDs.

ACE inhibitors for blood pressure (names ending in “-pril,” like lisinopril) are known for angioedema (deep swelling) but can also cause urticaria in some patients.

Antibiotics (e.g., penicillins), opiates, and radiocontrast agents can provoke hives in susceptible individuals.

What to do: If hives follow a new medication, call your clinician promptly.